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Structure paper

TitleThe gene-regulating proteins NONO and SFPQ assemble into ordered filaments.
Journal, issue, pagesCommun Biol, Vol. 9, Issue 1, Page 117, Year 2025
Publish dateDec 31, 2025
AuthorsTim Rasmussen / Jannik Küspert / Lars Schönemann / Dietmar Geiger / Bettina Böttcher /
PubMed AbstractProteins of the Drosophila behaviour/human splicing (DBHS) family are involved in many aspects of gene regulation and maintenance like transcription, splicing and DNA repair. DBHS proteins form ...Proteins of the Drosophila behaviour/human splicing (DBHS) family are involved in many aspects of gene regulation and maintenance like transcription, splicing and DNA repair. DBHS proteins form obligate homo- and heterodimers through interactions within a globular domain and can further dynamically oligomerise through α-helical coiled-coils, which is crucial for many functions. While the atomic structures of the dimers are established, the arrangement in higher oligomers is unknown. Here we present the structure of a filamentous NONO/SFPQ heterooligomer resolved by cryo-EM. The filaments form a double helix which is stabilized by an interdigitating network of coiled-coil interactions.
External linksCommun Biol / PubMed:41476260 / PubMed Central
MethodsEM (single particle)
Resolution3.3 - 3.9 Å
Structure data

EMDB-51413: NONO/SFPQ filament, overall map
Method: EM (single particle) / Resolution: 3.9 Å

EMDB-51417: NONO/SFPQ filament: local refinement single strand (strand 1)
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-51418: NONO/SFPQ filament: local refinment single strand (strand 2)
Method: EM (single particle) / Resolution: 3.5 Å

51438

9glc

EMDB-51438, PDB-9glc:
NONO/SFPQ filament: local refinement central units (strand 1)
Method: EM (single particle) / Resolution: 3.3 Å

51439

9gld

EMDB-51439, PDB-9gld:
NONO/SFPQ filament: local refinement central units (strand 2)
Method: EM (single particle) / Resolution: 3.3 Å

51471

9gni

EMDB-51471, PDB-9gni:
NONO/SFPQ filament: composite structure
Method: EM (single particle) / Resolution: 3.9 Å

Source
  • cricetulus griseus (Chinese hamster)
KeywordsNUCLEAR PROTEIN / filament / RNA binding / DNA binding / gene regulation

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