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Structure paper

TitleDefective cell-autonomous signalling and antigenic polyreactivity of B-cell receptors from chronic lymphocytic leukaemia stereotyped subset 1.
Journal, issue, pagesNat Commun, Year 2025
Publish dateAug 9, 2024 (structure data deposition date)
AuthorsCocomazzi, P.G. / Iatrou, A. / Minici, C. / Gounari, M. / Linder, A.T. / Akpinaroglu, C. / Patrone, M. / Broggini, L. / Frenquelli, M. / Sarrigeorgiou, I. ...Cocomazzi, P.G. / Iatrou, A. / Minici, C. / Gounari, M. / Linder, A.T. / Akpinaroglu, C. / Patrone, M. / Broggini, L. / Frenquelli, M. / Sarrigeorgiou, I. / Lymberi, P. / Petrakis, G. / Koletsa, T. / Scarfo, L. / Agathangelidis, A. / Jumaa, H. / Maity, P.C. / Ghia, P. / Stamatopoulos, K. / Degano, M.
External linksNat Commun / PubMed:41469389
MethodsX-ray diffraction
Resolution2.3 - 2.8 Å
Structure data

PDB-9gff:
BCR Fab from the subset 1 chronic lymphocytic leukaemia case P10015
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-9gfg:
BCR Fab from the subset 1 chronic lymphocytic leukaemia case P3129
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9gfh:
BCR Fab from the subset 1 chronic lymphocytic leukaemia case P1173
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CIT:
CITRIC ACID

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / B-cell receptor / Fab / chronicl lymphocytic leukaemia / BCR / chronic lymphocytic leukaemia / Fab fragment

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