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| Title | PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates. |
|---|---|
| Journal, issue, pages | Nat. Chem. Biol., Vol. 22, Page 802-812, Year 2026 |
| Publish date | Mar 13, 2025 (structure data deposition date) |
Authors | Zhao, Z. / Xu, W. / Feng, E.Y. / Cao, S. / Hermoso-Lopez, A. / Pena-Vega, P. / Lloyd, H.C. / Porter, A.K.D. / Guzman, M. / Zheng, N. / Woo, C.M. |
External links | Nat. Chem. Biol. / PubMed:41461925 |
| Methods | X-ray diffraction |
| Resolution | 2.93 Å |
| Structure data | ![]() PDB-9nr3: |
| Chemicals | ![]() ChemComp-ZN: |
| Source |
|
Keywords | LIGASE / ubiquitin ligase / native substrate / degron / glutamine synthetase / CRBN |
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