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TitleStructure-Guided Engineering of Tryptophan Hydroxylase Relieves Tunnel Congestion and Substrate Trapping to Enhance 5-Hydroxytryptophan Biosynthesis.
Journal, issue, pagesJ. Agric. Food Chem., Vol. 74, Page 1312-1325, Year 2026
Publish dateAug 25, 2025 (structure data deposition date)
AuthorsHan, J. / You, J. / Fan, Z. / Liu, F. / Zhang, H. / Zhu, R. / Chen, X. / Zhang, R. / Rao, Z.
External linksJ. Agric. Food Chem. / PubMed:41460668
MethodsX-ray diffraction
Resolution1.857 Å
Structure data

PDB-9wgz:
Tryptophan hydroxylase mutant - Y235S
Method: X-RAY DIFFRACTION / Resolution: 1.857 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / mutant

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