Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies.
Journal, issue, pages	J. Med. Chem., Vol. 69, Page 533-552, Year 2026
Publish date	Oct 17, 2024 (structure data deposition date)
Authors	Stewart, H.L. / Bordoni, C. / Jennings, C.E. / Al-Khawaldeh, I. / Martin, M.P. / Noble, R.A. / Phillips, N. / Pintar, S. / Prendergast, L. / Thomas, H.D. ...Stewart, H.L. / Bordoni, C. / Jennings, C.E. / Al-Khawaldeh, I. / Martin, M.P. / Noble, R.A. / Phillips, N. / Pintar, S. / Prendergast, L. / Thomas, H.D. / Wang, L.Z. / Watt, J.E. / Wittner, A. / Bronowska, A.K. / Cano, C. / Noble, M.E.M. / Wedge, S.R. / Waring, M.J.
External links	J. Med. Chem. / PubMed:41432179
Methods	X-ray diffraction
Resolution	2.423 - 3.163 Å
Structure data	PDB-9h42: EGFR wild type incomplex with 26007 Method: X-RAY DIFFRACTION / Resolution: 2.601 Å PDB-9h46: EGFR wild type in complex with 25328 Method: X-RAY DIFFRACTION / Resolution: 3.163 Å PDB-9h47: EGFR wild type in complex with 26313 Method: X-RAY DIFFRACTION / Resolution: 2.991 Å PDB-9s3x: EGFR (T790M,L858R) in complex with NCL-26007 Method: X-RAY DIFFRACTION / Resolution: 2.423 Å
Chemicals	PDB-1ir8: IM mutant of lysozyme PDB-1isa: STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS ChemComp-HOH: WATER PDB-1ir9: IM mutant of lysozyme PDB-1jlu: Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent
Source	homo sapiens (human)
Keywords	TRANSFERASE / KINASE / EGFR / INHIBITOR / covalent