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TitleStructural basis for substrate recruitment and catalytic ubiquitin transfer by the E2/E3 hybrid enzyme UBE2O.
Journal, issue, pagesJ. Biol. Chem., Vol. 302, Page 111073-111073, Year 2025
Publish dateApr 10, 2025 (structure data deposition date)
AuthorsKordic, D. / Williams, T.L. / Deszcz, L. / Ehrmann, J.F. / Arnese, R. / Schleiffer, A. / Clausen, T. / Meinhart, A.
External linksJ. Biol. Chem. / PubMed:41419192
MethodsX-ray diffraction
Resolution1.8 - 3 Å
Structure data

PDB-9quf:
Structure of a fungal Ube2O
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9qug:
Structure of a UBC-Ubiquitin conjugate
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-P4K:
polyethylene glycol

ChemComp-HOH:
WATER

Source
  • pyrenophora tritici-repentis (fungus)
  • homo sapiens (human)
KeywordsLIGASE / E2/E3 enzyme / E2/E3 enzyme UBC domain conjugated to ubiquitin

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