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TitleLigand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry.
Journal, issue, pagesSci Rep, Vol. 16, Page 2752-2752, Year 2025
Publish dateJun 23, 2025 (structure data deposition date)
AuthorsYan, J. / Min-DeBartolo, J. / Huang, C.S. / Sharif, M.N. / Li, L. / Fish, S. / Dower, C. / Murphy, D. / Andreyeva, T. / Liu, H. ...Yan, J. / Min-DeBartolo, J. / Huang, C.S. / Sharif, M.N. / Li, L. / Fish, S. / Dower, C. / Murphy, D. / Andreyeva, T. / Liu, H. / Han, X. / Zheng, W. / Ooi, J.H. / Edmonds, J. / Chen, T. / Maben, Z. / Stevens, C.R. / Goihberg, P. / Nocula-Lugowska, M. / Evans, S.M. / Mosyak, L. / Kelleher, K. / Dickinson, C. / Hegen, M. / Winkler, A. / Karlsson, F.
External linksSci Rep / PubMed:41413164
MethodsX-ray diffraction
Resolution2.86 Å
Structure data

PDB-9p8x:
Crystal structure of GITR in complex with ligand-non-competitive Ab#1 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / GITR / GITRL / Glucocorticoid-induced TNF receptor / TNFRSF18 / TNFR / TNF / Tumor necrosis factor receptor / antibody / Fab

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