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TitleEnzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors.
Journal, issue, pagesNat Commun, Vol. 17, Page 622-622, Year 2025
Publish dateMar 4, 2025 (structure data deposition date)
AuthorsMeng, Q. / Benckendorff, C. / Morrill, C. / Zhuo, Y. / Egerstrom, A. / Ni Cheallaigh, A. / Derrington, S.R. / Obexer, R. / Ortmayer, M. / Levy, C.W. ...Meng, Q. / Benckendorff, C. / Morrill, C. / Zhuo, Y. / Egerstrom, A. / Ni Cheallaigh, A. / Derrington, S.R. / Obexer, R. / Ortmayer, M. / Levy, C.W. / Finnigan, J.D. / Charnock, S.J. / Turner, N.J. / Miller, G.J. / Lovelock, S.L.
External linksNat Commun / PubMed:41402308
MethodsX-ray diffraction
Resolution2 - 2.24 Å
Structure data

PDB-9qci:
Crystal structure of PhoC mutant acid phosphatase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9qcj:
Crystal structure of PhoC wild type acid phosphatase
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • morganella morganii (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / Acid phosphatase

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