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TitleChimeras co-targeting antigens and Fc gamma RIIb trigger degradation of extracellular soluble proteins and pathological aggregates.
Journal, issue, pagesNat Commun, Vol. 17, Page 514-514, Year 2025
Publish dateMar 5, 2025 (structure data deposition date)
AuthorsDu, M. / Li, N. / Li, T. / Zhao, Z. / Liu, H. / Li, X. / Gong, N. / Duan, B. / Wang, W. / Jian, Y. ...Du, M. / Li, N. / Li, T. / Zhao, Z. / Liu, H. / Li, X. / Gong, N. / Duan, B. / Wang, W. / Jian, Y. / Ma, W. / Zhang, X. / Wang, Y. / Zhang, Z. / Bai, Y. / Wang, X. / Wang, C. / Liu, J. / Guan, X. / Zhou, F. / Li, L. / Zhu, X. / Lei, Y. / Duan, Y. / Han, G. / Wei, P. / Gao, S. / Wang, S. / Chen, A. / Huang, Y. / Yang, H. / Xue, X. / Zhang, H.
External linksNat Commun / PubMed:41372196
MethodsX-ray diffraction
Resolution1.66 Å
Structure data

PDB-9m5b:
A Human Fc Receptor Ectodomain in Complex With a Fab
Method: X-RAY DIFFRACTION / Resolution: 1.66 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody FcRn

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