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Structure paper

TitleStructure guided analysis of KRAS G12 mutants in HLA-A*11:01 reveals a length encoded immunogenic advantage in G12D.
Journal, issue, pagesCommun Biol, Year 2025
Publish dateJul 20, 2023 (structure data deposition date)
AuthorsZhu, J. / Chen, Z. / Xu, X. / Wang, Y. / Liu, P. / Wen, M. / Wang, Q. / He, Y. / Jin, H. / Xue, H. ...Zhu, J. / Chen, Z. / Xu, X. / Wang, Y. / Liu, P. / Wen, M. / Wang, Q. / He, Y. / Jin, H. / Xue, H. / Wang, S. / Xu, K. / Zhao, L.
External linksCommun Biol / PubMed:41339521
MethodsX-ray diffraction
Resolution1.79 - 3.095 Å
Structure data

PDB-8k4t:
Crystal structure of HLA-A*11:01 in complex with KRAS G12C peptide (VVVGACGVGK)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8k4v:
Crystal structure of HLA-A*11:01 in complex with KRAS G12R peptide (VVVGARGVGK)
Method: X-RAY DIFFRACTION / Resolution: 3.095 Å

PDB-8k50:
Crystal structure of HLA-A*11:01 in complex with KRAS G12V peptide (VVVGARGVGK)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-9uv8:
Crystal structure of HLA-A*11:01 in complex with KRAS G12D 9-mer peptide (VVGADGVGK)
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-9wve:
Crystal structure of HLA-A*11:01 in complex with KRAS G12A 10-mer peptide (VVVGAAGVGK)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-9wvf:
Crystal structure of HLA-A*11:01 in complex with KRAS G12S 10-mer peptide (VVVGASGVGK)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / cancer immunotherapy / Complex

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