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TitleDevelopment of a p62 biodegrader for autophagy targeted degradation.
Journal, issue, pagesNat Commun, Vol. 16, Page 10858-10858, Year 2025
Publish dateOct 9, 2024 (structure data deposition date)
AuthorsThiel, Z. / Marcellin, D. / Manneville, C. / Goretzki, B. / Egger, L. / Maher, R. / Siccardi, N. / Torres, L. / Probst, A. / Muller, C.S. ...Thiel, Z. / Marcellin, D. / Manneville, C. / Goretzki, B. / Egger, L. / Maher, R. / Siccardi, N. / Torres, L. / Probst, A. / Muller, C.S. / George, N. / Vogel, M. / Sinterhauf, S. / Lavoisier, A. / Choi, J.Y. / Forcellino, L. / Landshammer, A. / Hauck, P. / Be, C. / Villard, F. / Gutmann, S. / Meyer, M. / Freuler, F. / Hinniger, A. / Fernandez, C. / Chau, S. / Patoor, M. / Sansig, G. / Mitchell, G. / Nyfeler, B.
External linksNat Commun / PubMed:41339312
MethodsX-ray diffraction
Resolution1.73 Å
Structure data

PDB-9h1j:
Crystal structure of the p62 UBA domain bound to VHH 6C10
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsPROTEIN TRANSPORT / Autophagy / Macroautophagy / ubiquitin binding proteins

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