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TitleStructural basis for MEKK2 dimerization and substrate recognition.
Journal, issue, pagesNat Commun, Vol. 17, Page 193-193, Year 2025
Publish dateJun 18, 2025 (structure data deposition date)
AuthorsVish, K.J. / Huet-Calderwood, C. / Ha, B.H. / Calderwood, D.A. / Boggon, T.J.
External linksNat Commun / PubMed:41318559
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-9p6a:
The catalytic domain of MEKK2 in complex with ponatinib
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-0LI:
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Kinase / ponatinib / AP24534 / MAP3K / MAP kinase kinase kinase

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