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TitlePTPN9 dephosphorylates IGF1R Y1165/1166 and alleviates IGF1R-mediated resistance to tyrosine kinase inhibitor in cholangiocarcinoma.
Journal, issue, pagesJ Exp Clin Cancer Res, Vol. 44, Page 332-332, Year 2025
Publish dateMar 31, 2025 (structure data deposition date)
AuthorsHu, J.M. / Liu, H.Q. / Zhang, M.H. / Chen, T.L. / Shi, A.D. / Gao, Q. / Liu, Y.J. / Wang, X. / Sun, K.Y. / Deng, J. ...Hu, J.M. / Liu, H.Q. / Zhang, M.H. / Chen, T.L. / Shi, A.D. / Gao, Q. / Liu, Y.J. / Wang, X. / Sun, K.Y. / Deng, J. / Xu, Y.F. / Pan, C. / Li, K.S. / Zhang, Z.L.
External linksJ Exp Clin Cancer Res / PubMed:41275311
MethodsX-ray diffraction
Resolution1.999 Å
Structure data

PDB-9ua8:
structure of PTP-MEG2 and IFG1R-pY1165/pY1166 peptide complex
Method: X-RAY DIFFRACTION / Resolution: 1.999 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Complex.

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