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TitleStructural determination of the human taurine transporter TauT reveals the mechanism of substrate and inhibitor recognition.
Journal, issue, pagesCell Rep, Vol. 44, Issue 12, Page 116591, Year 2025
Publish dateNov 19, 2025
AuthorsYishuo Lu / Dian Ding / Hongyi Chen / Peijun Jiang / Juan Luo / Hui Shan / Guangxi Wang / Jianyuan Luo / Yuxin Yin /
PubMed AbstractTaurine, a sulfur-containing amino acid, is vital for human health because of its antioxidant, anti-inflammatory, and osmoregulatory properties. Its homeostasis is maintained by the Na/Cl-dependent ...Taurine, a sulfur-containing amino acid, is vital for human health because of its antioxidant, anti-inflammatory, and osmoregulatory properties. Its homeostasis is maintained by the Na/Cl-dependent taurine transporter (TauT). Here, we present five atomic structures of human TauT: apo, taurine bound, and complexes with three taurine-mimetic inhibitors, including β-alanine, γ-aminobutyric acid (GABA), and guanidinoethyl sulfonate (GES). The structures of taurine-, β-alanine-, and GABA-bound human TauT (hTauT) in complex with NaCl adopt an occluded conformation, with ligands binding in a central pocket. With KCl, GES-bound hTauT adopts an inward-facing conformation, with two GES positioned along the substrate translocation pathway in a bipartite manner: one in the deep central cavity and the other precluding structural transition to the occluded state. The radioactive taurine uptake analyses clearly demonstrate the impact of residues on taurine recognition and inhibitor selection. These structures provide insights into the overall architecture, substrate coordination, and inhibitor recognition mechanism of TauT.
External linksCell Rep / PubMed:41269860
MethodsEM (single particle)
Resolution2.9 - 3.3 Å
Structure data

62564

9kts

EMDB-62564, PDB-9kts:
Structure of TauT in the apo state
Method: EM (single particle) / Resolution: 3.2 Å

62565

9ktt

EMDB-62565, PDB-9ktt:
Structure of TauT in complex with taurine
Method: EM (single particle) / Resolution: 3.3 Å

62566

9ktu

EMDB-62566: Structure of TauT in complex with taurine
PDB-9ktu: Structure of TauT in complex with beta-alanine
Method: EM (single particle) / Resolution: 3.2 Å

62567

9ktv

EMDB-62567, PDB-9ktv:
Structure of TauT in complex with GABA
Method: EM (single particle) / Resolution: 3.0 Å

62569

9ktx

EMDB-62569, PDB-9ktx:
Structure of TauT in complex with Guanidinoethyl sulfonate
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TAU:
2-AMINOETHANESULFONIC ACID

ChemComp-NA:
Unknown entry

ChemComp-BAL:
BETA-ALANINE

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID

ChemComp-3S5:
Taurocyamine

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / TauT / SLC6A6 / taurine transporter

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