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TitleA rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models.
Journal, issue, pagesSci Transl Med, Vol. 17, Page eady9025-eady9025, Year 2025
Publish dateApr 2, 2025 (structure data deposition date)
AuthorsWu, X. / Zhu, L. / Liang, S. / Chang, Z. / Wang, Y. / Zou, Q. / Xu, Z. / Zhang, D. / Hu, J. / Geng, S. ...Wu, X. / Zhu, L. / Liang, S. / Chang, Z. / Wang, Y. / Zou, Q. / Xu, Z. / Zhang, D. / Hu, J. / Geng, S. / Li, Z. / Yu, W. / Hu, Z. / Chen, M. / Cao, K. / Jia, B. / Wei, H. / Cai, R. / Long, J. / Yang, X. / Yang, Q. / Yu, Z. / Shi, L. / Xu, B. / Zheng, Y. / Meng, S. / Cai, J. / Zhou, G. / Zhu, K. / Dou, Y. / Lou, Z. / Li, M. / Wu, Y. / Wu, Z.
External linksSci Transl Med / PubMed:41259535
MethodsX-ray diffraction
Resolution2.89 Å
Structure data

PDB-9ub6:
Crystal structure of SFTSV Gn head with nanobody Nb261
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • sfts virus hb29
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / SFTSV

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