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TitleUnveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies.
Journal, issue, pagesProtein Sci., Vol. 34, Page e70367-e70367, Year 2025
Publish dateAug 29, 2023 (structure data deposition date)
AuthorsNadal-Bufi, F. / Van Gysel, M. / Brustenga, C. / Savoyen, P. / Mathieu, C. / Gobert, A. / Sonveaux, P. / Spillier, Q. / Fillet, M. / Wouters, J. / Frederick, R.
External linksProtein Sci. / PubMed:41229320
MethodsX-ray diffraction
Resolution2.98 Å
Structure data

PDB-8qde:
Crystal structure of a truncated human L-Lactate Dehydrogenase B protein in complex with NADH and oxamate
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

Chemicals

ChemComp-NAI:
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE

ChemComp-OXM:
OXAMIC ACID

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-SO4:
SULFATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Complex / Truncated protein

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