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TitleGSH as an A-A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility.
Journal, issue, pagesAdv Sci, Page e19368-e19368, Year 2025
Publish dateJul 13, 2024 (structure data deposition date)
AuthorsChen, T.J. / Lo, C.J. / Wu, M.J. / Sit, W.Y. / Hsu, H.Y. / Huang, Y.C. / Lu, C.H. / Chen, Y.L. / Fang, W.K. / Yang, S.M. ...Chen, T.J. / Lo, C.J. / Wu, M.J. / Sit, W.Y. / Hsu, H.Y. / Huang, Y.C. / Lu, C.H. / Chen, Y.L. / Fang, W.K. / Yang, S.M. / Chen, P.L. / Haraguchi, T. / Hiraoka, Y. / Lin, C.Y. / Cheng, M.L. / Yang, M.H. / Kung, H.J. / Wang, W.C.
External linksAdv Sci / PubMed:41215470
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-9iqq:
Crystal structure of PKM2 in complex with a natural activator
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-GSH:
GLUTATHIONE

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Pyruvate kinase / tetramer / activator

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