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TitleThe Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility.
Journal, issue, pagesCell Rep, Vol. 44, Issue 11, Page 116475, Year 2025
Publish dateNov 25, 2025
AuthorsXue-Tong Zhao / Duy Trong Vien Diep / Louis Percifull / Rebecca Martina Fausten / Marie Hugenroth / Pascal Höhne / Beatriz Leite / Bianca Marie Esch / Javier Collado / Jenny Keller / Stephan Wilmes / Meryem Aysenur Turhan / Mike Wälte / Thomas Becker / Daniel Kümmel / Christian Schuberth / Rubén Fernández-Busnadiego / Florian Fröhlich / Roland Wedlich-Söldner / Maria Bohnert /
PubMed AbstractOrganelle motility enables strategic cellular reorganizations. In yeast, this process depends on the actin cytoskeleton, type V myosin motor proteins, and organelle-specific myosin adaptor proteins. ...Organelle motility enables strategic cellular reorganizations. In yeast, this process depends on the actin cytoskeleton, type V myosin motor proteins, and organelle-specific myosin adaptor proteins. While the myosin adaptors for most organelles are known, the coupling of myosin to lipid droplets (LDs), the cellular lipid storage organelles, remained enigmatic. Using genome-wide screening, we identified Ldm1 (lipid droplet motility 1/Yer085c) as a myosin adaptor. Ldm1 binds to the globular tail domain of the myosin Myo2 and to the LD surface protein Ldo16 to enable actin-dependent LD motility. Ldo16 has additional roles in LD contact sites to the vacuole and the endoplasmic reticulum, suggesting a coordination of LD motility and organelle tethering. Ldm1 has a second role in mitochondrial transport, and elevated Ldm1 levels rescue defects of the mitochondrial Myo2-adaptors Mmr1/Ypt11. Our work identifies the molecular machinery for LD motility and contributes to a comprehensive understanding of acto-myosin-based cellular reorganization.
External linksCell Rep / PubMed:41201089
MethodsEM (tomography)
Structure data

EMDB-54480: Tomogram of unbudded yeast cell overexpressing Ldm1
Method: EM (tomography)

EMDB-54483: Tomogram of yeast cell overexpressing Ldm1, treated with alpha-factor
Method: EM (tomography)

EMDB-54486: Tomogram of yeast cell overexpressing Ldm1, treated with alpha-factor (unbudded region)
Method: EM (tomography)

EMDB-54487: Tomogram of yeast cell overexpressing Ldm1, treated with alpha-factor(bud region)
Method: EM (tomography)

EMDB-54489: Tomogram of a yeast cell treated with alpha-factor (bud region)
Method: EM (tomography)

EMDB-54497: Tomogram of a yeast cell treated with alpha-factor (bud region)
Method: EM (tomography)

Source
  • Saccharomyces cerevisiae (brewer's yeast)

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