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TitleStructural basis for a potent human neutralizing antibody targeting a conserved epitope on the H7 hemagglutinin head.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 122, Issue 45, Page e2503008122, Year 2025
Publish dateNov 11, 2025
AuthorsJunxin Li / Min Wang / Yang Yang / Limin Zhang / Lvyan Liu / Wei Yang / Yun Peng / Xu Zhang / Bin Yuan / Qi Peng / Xiaolu Yang / Yixin Chen / George F Gao / Yi Shi / Xiaochun Wan /
PubMed AbstractZoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential. Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing ...Zoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential. Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing and controlling major outbreaks. Here, we isolated a human gene-encoded antibody, designated 6Y13, from a survivor of H7N9 infection. This antibody recognized the hemagglutinins (HAs) of the representative H7 subtype zoonotic viruses spanning two decades of antigenic evolution and potently neutralized epidemic H7N9 viruses in vitro. Moreover, 6Y13 conferred complete protection in mice against lethal H7N9 challenge in both prophylactic and therapeutic experiments. Structural analysis by cryoelectron microscopy indicated that 6Y13 binds to a unique conserved site on the HA head, distinct from the receptor-binding site and lateral patch. Nevertheless, 6Y13 efficiently blocked viral receptor binding without interfering with HA receptor binding, independent of Fc-mediated steric hindrance. Our findings provide a promising therapeutic candidate against pan-H7 subtype viruses and are beneficial for the design of H7 subtype influenza vaccine immunogens.
External linksProc Natl Acad Sci U S A / PubMed:41196357 / PubMed Central
MethodsEM (single particle)
Resolution3.1 Å
Structure data

63103

9lho

EMDB-63103, PDB-9lho:
CryoEM structure of H7 hemagglutinin in complex with a human neutralizing antibody 6Y13
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • influenza a virus (a/duck/chiba/25-51-14/2013(h7n1))
  • homo sapiens (human)
KeywordsVIRAL PROTEIN

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