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TitleKEAP1 C151 active site catalysis drives electrophilic signaling to upregulate cytoprotective enzyme expression.
Journal, issue, pagesRedox Biol, Vol. 88, Page 103906-103906, Year 2025
Publish dateJul 9, 2025 (structure data deposition date)
AuthorsSchnell, M.R. / Zhai, T. / Ragwan, E.R. / Jung, H. / Zhang, J. / Lagalante, A.F. / Kung, Y. / Kraut, D.A. / Huang, Z. / Eggler, A.L.
External linksRedox Biol / PubMed:41187500
MethodsX-ray diffraction
Resolution1.801 Å
Structure data

PDB-9phr:
BTB modified at C151 with monobimane
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

Chemicals

ChemComp-9UM:
3-(bromomethyl)-2,5,6-trimethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / BTB modified at C151 with monobimane

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