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Structure paper

TitleA special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly.
Journal, issue, pagesNat Commun, Vol. 16, Page 9644-9644, Year 2025
Publish dateNov 6, 2024 (structure data deposition date)
AuthorsHuang, S.J. / Ma, D.F. / Yu, C. / Li, J. / Tu, X. / Huang, Z. / Qi, Y. / Ou, J.Y. / Feng, J.X. / Yu, B. ...Huang, S.J. / Ma, D.F. / Yu, C. / Li, J. / Tu, X. / Huang, Z. / Qi, Y. / Ou, J.Y. / Feng, J.X. / Yu, B. / Cao, Y.L. / Yue, J.X. / Hu, J. / Li, M. / Lu, Y. / Yan, L. / Gao, S.
External linksNat Commun / PubMed:41173874
MethodsX-ray diffraction
Resolution2.12 - 2.81 Å
Structure data

PDB-9kfd:
Truncated Fzo1,GTP-bound
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-9kfe:
Truncated Fzo1 with modified LB, GTP-bound
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-9kff:
Truncated Fzo1 with modified LB, transition-like state
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-BEF:
BERYLLIUM TRIFLUORIDE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE / Fzo1 / dynamin / mitofusin

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