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| Title | Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 68, Page 23050-23077, Year 2025 |
| Publish date | Aug 15, 2025 (structure data deposition date) |
 Authors | Patel, S. / Chen, H. / Varfolomeev, E. / Kwon, Y. / Ramaswamy, S. / Kohli, P.B. / Quinn, J.G. / Webster, J.D. / Mao, J. / Chen, Y. ...Patel, S. / Chen, H. / Varfolomeev, E. / Kwon, Y. / Ramaswamy, S. / Kohli, P.B. / Quinn, J.G. / Webster, J.D. / Mao, J. / Chen, Y. / Fong, R. / Demircioglu, F.E. / Lupardus, P. / Stivala, C. / Hamilton, G.L. / Siu, M. / Sujatha-Bhaskar, S. / Mohanan, V. / Adedeji, A.O. / Santagostino, S.F. / Maher, J. / McKenzie, B. / Rothenberg, M.E. / Johnson, A. / Vucic, D. |
 External links | J. Med. Chem. / PubMed:41165210 |
| Methods | X-ray diffraction |
| Resolution | 2.05 - 2.49 Å |
| Structure data |  PDB-9q31:  PDB-9q32: |
| Chemicals |  PDB-1cnu:  ChemComp-BR:  ChemComp-CL:  ChemComp-NA:  ChemComp-TME:  ChemComp-HOH:  PDB-1cnv: |
| Source |
|
 Keywords | TRANSFERASE/Inhibitor / kinase / inhibitor / TRANSFERASE / TRANSFERASE-Inhibitor complex |
homo sapiens (human)