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TitleNRBF2 homodimerization by its coiled-coil domain strengthens association with the PtdIns3K complex mediated by the MIT domain to promote autophagy.
Journal, issue, pagesAutophagy, Vol. 22, Page 168-181, Year 2026
Publish dateSep 15, 2025 (structure data deposition date)
AuthorsLi, N. / Li, X. / Qiu, X. / Pan, X. / Wu, S. / Chen, J. / Liu, R. / Lu, J. / Yue, Z. / Zhao, Y.
External linksAutophagy / PubMed:41162841
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-9wt3:
NRBF2 coiled coil domain promotes autophagy by strengthening association with Vps15 in the PI3KC3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsSTRUCTURAL PROTEIN / PI3KC3 complex / NRBF2 / Autophagy

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