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TitleGlycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2521209122-e2521209122, Year 2025
Publish dateSep 24, 2025 (structure data deposition date)
AuthorsPolycarpou, A. / Wagner-Gamble, T. / Greenlaw, R. / O'Neill, L. / Kanabar, V. / Alrehaili, A. / Jeon, Y. / Baker, J. / Bafadhel, M. / Khan, H. ...Polycarpou, A. / Wagner-Gamble, T. / Greenlaw, R. / O'Neill, L. / Kanabar, V. / Alrehaili, A. / Jeon, Y. / Baker, J. / Bafadhel, M. / Khan, H. / Malim, M.H. / Romano, M. / Farrar, C.A. / Smolarek, D. / Martinez-Nunez, R. / Doores, K.J. / Wallis, R. / Klavinskis, L.S. / Sacks, S.H.
External linksProc. Natl. Acad. Sci. USA / PubMed:41134631
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-9srk:
Structure of collectin-11 (CL-11) carbohydrate-recognition domain in complex with L-fucose
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-FUL:
beta-L-fucopyranose

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Innate immunity / complement / lectin

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