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TitleNovel Humanized Anti-HER3 Antibodies: Structural Characterization and Therapeutic Activity.
Journal, issue, pagesAntibodies, Vol. 14, Year 2025
Publish dateJan 16, 2025 (structure data deposition date)
AuthorsMuzi, A. / Arriga, R. / Bulfaro, G. / Fata, F. / Costanzo, A. / Chiarini, V. / Cappelletti, M. / Ferrara, F.F. / Bucci, F. / Montemiglio, L.C. ...Muzi, A. / Arriga, R. / Bulfaro, G. / Fata, F. / Costanzo, A. / Chiarini, V. / Cappelletti, M. / Ferrara, F.F. / Bucci, F. / Montemiglio, L.C. / Savino, C. / Marra, E. / Ciliberto, G. / Aurisicchio, L. / Vallone, B. / Roscilli, G.
External linksAntibodies / PubMed:41133678
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-9i1q:
HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SCN:
THIOCYANATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / growth factor receptor / monoclonal antibody / cancer / complex

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