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TitleHijacking a bacterial ABC transporter for genetic code expansion.
Journal, issue, pagesNature, Vol. 647, Page 1045-1053, Year 2025
Publish dateMay 30, 2025 (structure data deposition date)
AuthorsIype, T. / Fottner, M. / Bohm, P. / Piedrafita, C. / Moller, Y. / Groll, M. / Lang, K.
External linksNature / PubMed:41094137
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-9rd1:
OppA from E. coli in complex with GSisoK
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

PDB-1jhr:
Three-dimensional Structure of CobT in Complex with Reaction Products of 2-hydroxypurine and NaMN

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • synthetic construct (others)
KeywordsTRANSPORT PROTEIN / Substrate recognition specificity / Binding pocket plasticity / Transporter-ligand interactions / Structural basis for selective uptake / Scaffold accommodation

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