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TitleFolding-mediated secretion of pure bispecific antibodies.
Journal, issue, pagesNat. Biotechnol., Year 2025
Publish dateJan 16, 2025 (structure data deposition date)
AuthorsTilegenova, C. / Liu, T. / Zhao, Q. / Are, M. / Zhao, Y. / Choi, W.S. / Bhaumik, A. / Steele, R. / Manieri, N.A. / Turegun, B. ...Tilegenova, C. / Liu, T. / Zhao, Q. / Are, M. / Zhao, Y. / Choi, W.S. / Bhaumik, A. / Steele, R. / Manieri, N.A. / Turegun, B. / Ni, A. / Cardoso, R.M.F. / Shaffer, P. / Clark, D. / Ernst, R. / Li, W. / Taylor, T. / Swaminathan, S.K. / Ramaraju, B. / Liaw, K. / Jacobs, S.A. / Sharma, S. / Cheung, W.C. / Zwolak, A.
External linksNat. Biotechnol. / PubMed:41057658
MethodsX-ray diffraction
Resolution1.84 - 2.6 Å
Structure data

PDB-9mvx:
Crystal structure of knob-in-hole immunoglobulin G1 Fc heterodimer with P374A
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

PDB-9n8q:
Crystal structure of Trastuzumab Fab with P151A
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HUMAN FC FRAGMENT / IMMUNE RESPONSE / KNOB / HOLE / KNOB-IN-HOLE / KIH / ProAla / Proline-to-alanine / bispecific antibody / bsAb / bsIgG / Cis-peptide / HUMAN FAB FRAGMENT / Trastuzumab / Fab

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