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TitleA nonenzymatic effector disrupts Bacteroides cell wall homeostasis via OmpA targeting to mediate interbacterial competition.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Year 2025
Publish dateMay 5, 2025 (structure data deposition date)
AuthorsHe, J. / Chen, Z. / Jiang, K. / Yang, Y. / Li, W. / Wang, X. / Xu, X. / Zheng, S. / Jiao, X. / Chen, X. ...He, J. / Chen, Z. / Jiang, K. / Yang, Y. / Li, W. / Wang, X. / Xu, X. / Zheng, S. / Jiao, X. / Chen, X. / Huo, L. / Lim, B. / Liu, S.J. / Gao, X.
External linksProc. Natl. Acad. Sci. USA / PubMed:41055976
MethodsX-ray diffraction
Resolution1.9 - 2.72 Å
Structure data

PDB-9uu0:
The structure of Bacteroides fragilis T6SS effector BteO
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-9uu1:
Bacteroides fragilis T6SS immunity protein BtiO
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9uu2:
Outer membrane protein OmpA-c-like domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

Source
  • escherichia coli (strain k12) (bacteria)
  • bacteroides fragilis (bacteria)
  • bacteroides fragilis nctc 9343 (bacteria)
KeywordsTOXIN / Bacteroides fragilis T6SS effector / ANTITOXIN / Bacteroides fragilis T6SS immunity protein / STRUCTURAL PROTEIN / Outer membrane protein OmpA-c-like domain

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