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TitleA miniature CRISPR-Cas10 enzyme confers immunity by inhibitory signalling.
Journal, issue, pagesNature, Vol. 647, Page 997-1004, Year 2025
Publish dateMar 24, 2025 (structure data deposition date)
AuthorsDoherty, E.E. / Adler, B.A. / Yoon, P.H. / Hsieh, K. / Loi, K. / Armbruster, E.G. / Lahiri, A. / Bolling, C.S. / Wilcox, X.E. / Akkati, A. ...Doherty, E.E. / Adler, B.A. / Yoon, P.H. / Hsieh, K. / Loi, K. / Armbruster, E.G. / Lahiri, A. / Bolling, C.S. / Wilcox, X.E. / Akkati, A. / Iavarone, A.T. / Pogliano, J. / Doudna, J.A.
External linksNature / PubMed:41034576
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-9nwn:
Structure of minimal CRISPR polymerase bound to ApNHpp
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-ZAN:
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM / cyclase / palm domain / cyclic oligonucleotide / mCpol

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