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TitleStructural basis of biofilm-forming functional amyloid FapC formation.
Journal, issue, pagesSci Adv, Vol. 11, Issue 39, Page eadx7829, Year 2025
Publish dateSep 26, 2025
AuthorsKasper Holst Hansen / Mert Golcuk / Chang Hyeock Byeon / Abdulkadir Tunc / Emilie Buhl Plechinger / Morten K D Dueholm / James F Conway / Maria Andreasen / Mert Gur / Ümit Akbey /
PubMed AbstractBiofilm-protected causes chronic infections that are difficult to treat. FapC, the major biofilm-forming functional amyloid in , is essential for biofilm integrity, yet its structural details remain ...Biofilm-protected causes chronic infections that are difficult to treat. FapC, the major biofilm-forming functional amyloid in , is essential for biofilm integrity, yet its structural details remain unresolved. Using an integrative structural biology approach, we combine a solution nuclear magnetic resonance-based structural ensemble of unfolded monomeric FapC, a ~3.3-angstrom-resolution cryo-electron microscopy (cryo-EM) density map of FapC fibril, and all-atom molecular dynamics (MD) simulations to capture the transition from the unfolded to folded monomer to the fibrillar fold, providing a complete structural view of FapC biogenesis. Cryo-EM reveals a unique irregular triple-layer β solenoid cross-β fibril composed of a single protofilament. MD simulations initiated from monomeric and fibrillar FapC mapped structural transitions, offering mechanistic insights into amyloid assembly and disassembly. Understanding FapC reveals how exploits functional amyloids for biofilm formation, and establishes a structural and mechanistic foundation for developing therapeutics targeting biofilm-related infection and antimicrobial resistance.
External linksSci Adv / PubMed:40991694 / PubMed Central
MethodsEM (helical sym.)
Resolution3.3 Å
Structure data

49649

9nqd

EMDB-49649, PDB-9nqd:
Structure of Pseudomonas FapC Biofilm-Forming Functional Amyloid
Method: EM (helical sym.) / Resolution: 3.3 Å

Source
  • pseudomonas fluorescens (bacteria)
KeywordsSTRUCTURAL PROTEIN / FapC Functional Amyloid Pseudomonas C / AMYLOID / FIBRIL / BIOFILM / FUNCTIONAL AMYLOID

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