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TitleStructural insights into the adenosylcobinamide-phosphate guanylyltransferase activity of CobU from Akkermansia muciniphila.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 329, Page 147810-147810, Year 2025
Publish dateJun 18, 2025 (structure data deposition date)
AuthorsJiang, M. / Kong, C. / Wei, Q. / Guo, S. / Chen, X. / Li, Q. / Wang, M.
External linksInt. J. Biol. Macromol. / PubMed:40976292
MethodsX-ray diffraction
Resolution1.85 - 2.4 Å
Structure data

PDB-9vio:
Crystal strcture of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase CobU from Akkermansia muciniphila, crystal form I
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9vip:
Crystal strcture of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase CobU from Akkermansia muciniphila, crystal form II
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9vis:
Crystal strcture of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase CobU from Akkermansia muciniphila in complex with AdoCbi-GDP
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-9vit:
Crystal strcture of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase CobU H49A from Akkermansia muciniphila in complex with GTP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MLA:
MALONIC ACID

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

PDB-1er6:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-3PO:
TRIPHOSPHATE

Source
  • akkermansia muciniphila atcc baa-835 (bacteria)
KeywordsTRANSFERASE / VB12 / Cobamide remodeling / CobU / adenosylcobinamide kinase / adenosylcobinamide phosphate guanylyltransferase / Akkermansia muciniphila

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