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Structure paper

TitleDrosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2511388122-e2511388122, Year 2025
Publish dateJun 30, 2025 (structure data deposition date)
AuthorsStanhope, S.C. / Singhal, K. / Morato, N.M. / Feng, Y. / Meng, G. / Marlin, M.N. / Kotanko, C.C. / Jarrett, M.M. / Mesecar, A.D. / Cooks, R.G. / Weake, V.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:40971386
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-9pdh:
X-ray structure of WT Drosophila Ahcy bound to NAD and adenosine at 2.50 A
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-ADN:
ADENOSINE

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsHYDROLASE / S-adenosylhomocysteinase (Ahcy) / one-carbon metabolism / redox homeostasis / redox-regulation / DESI-MS / retinal degeneration / Drosophila

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