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Structure paper

TitleOptimal TELSAM-Target Protein Linker Character is Target Protein-Dependent.
Journal, issue, pagesBiorxiv, Year 2025
Publish dateAug 23, 2024 (structure data deposition date)
AuthorsPedroza Romo, M.J. / Keliiliki, A. / Averett, J.C. / Gonzalez, J.F. / Noakes, E. / Wilson, E.W. / Smith, C. / Averett, B. / Hansen, D. / Nickles, R. ...Pedroza Romo, M.J. / Keliiliki, A. / Averett, J.C. / Gonzalez, J.F. / Noakes, E. / Wilson, E.W. / Smith, C. / Averett, B. / Hansen, D. / Nickles, R. / Bradford, M. / Soleimani, S. / Smith, T. / Nawarathnage, S. / Samarwickrama, P. / Kelsch, A. / Bunn, D. / Stewart, C. / Abiodun, W. / Tsubaki, E. / Brown, S. / Doukov, T.I. / Moody, J.D.
External linksBiorxiv / PubMed:40950120
MethodsX-ray diffraction
Resolution1.57 - 3.542 Å
Structure data

PDB-9db5:
A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-9dvg:
Crystal Structure of a DARPin Fused to the 1TEL Crystallization Chaperone via a Direct Helical Fusion in a 2-Fold Crystal Form
Method: X-RAY DIFFRACTION / Resolution: 3.542 Å

Chemicals

ChemComp-ACY:
ACETIC ACID

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPROTEIN BINDING / TELSAM / DARPin / ETV6 / Designed Ankyrin Repeat Protein

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