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TitleA rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2.
Journal, issue, pagesNat. Biotechnol., Year 2025
Publish dateApr 28, 2025 (structure data deposition date)
AuthorsChu, Y. / Chen, S. / Yang, M. / Chen, Y. / Fang, H. / Huang, P. / Xie, Y. / Sun, C. / Zhang, B. / Li, L. ...Chu, Y. / Chen, S. / Yang, M. / Chen, Y. / Fang, H. / Huang, P. / Xie, Y. / Sun, C. / Zhang, B. / Li, L. / Mu, H. / Song, D. / Cheng, W. / Wang, C. / Jiang, W. / Xu, X. / He, Z. / Liu, M. / Ma, J. / Cao, J. / Gao, J. / Shen, J. / Zhang, L. / Bai, Y. / Liu, Z. / Chen, J. / Dai, S. / Zeng, Y.A. / Zhao, Y. / Zhou, H. / Chen, C. / Ru, H. / Tan, L. / Chi, X. / Wang, F. / Gao, D. / Lin, M. / Deng, X. / Jiang, H.
External linksNat. Biotechnol. / PubMed:40931108
MethodsX-ray diffraction
Resolution2.29 Å
Structure data

PDB-9r1p:
Crystal structure of STUB1 complexed with a compound molecule
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

Chemicals

PDB-1jbj:
CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / STIP1 homology and U-Box containing protein 1 / E3 ubiquitin ligase

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