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Structure paper

TitleMolecular mechanisms underlying HRK interaction with BCL-XL and BCL-2 reveal specificity determinants for BH3 mimetics.
Journal, issue, pagesIscience, Vol. 28, Page 113309-113309, Year 2025
Publish dateJan 10, 2025 (structure data deposition date)
AuthorsWang, J. / Guo, M. / Dai, S. / Wei, H.
External linksIscience / PubMed:40894900
MethodsX-ray diffraction
Resolution2.32 - 2.97 Å
Structure data

PDB-9lgu:
Crystal structure of Bcl-xL in complex with stapled HRK peptide
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

PDB-9li8:
Crystal structure of Bcl-xL in complex with HRK BH3 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / BCL-2 family / mitochondrial apoptosis / BH3 Mimetics / BH3-only proteins

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