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TitleDefining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex.
Journal, issue, pagesCancer Discov, Vol. 15, Page 2505-2529, Year 2025
Publish dateNov 30, 2024 (structure data deposition date)
AuthorsYuan, L. / Ji, W. / Dwyer, B.G. / Lu, J. / Bian, J. / Colombo, G.M. / Martinez, M.J. / Fernandez, D. / Phillips, N.A. / Tang, M.T. ...Yuan, L. / Ji, W. / Dwyer, B.G. / Lu, J. / Bian, J. / Colombo, G.M. / Martinez, M.J. / Fernandez, D. / Phillips, N.A. / Tang, M.T. / Zhou, C.W. / Quispe Calla, N.E. / Guzman Huancas, C. / Eckart, M. / Tran, J. / Jones, H.M. / Qiu, T. / Doench, J.G. / Rees, M.G. / Roth, J.A. / Cameron, M.D. / Charville, G.W. / Kuo, C.J. / Dixon, S.J. / Zhang, T. / Hinshaw, S.M. / Gray, N.S. / Corsello, S.M.
External linksCancer Discov / PubMed:40891634
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-9ek5:
TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

PDB-1bld:
BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TRIM21 / ubiquitin / ubiquitin ligase / small molecule / protein degradation / innate immunity / cancer / therapeutics

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