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Structure paper

TitleDevelopment of D-box peptides to inhibit the anaphase-promoting complex/cyclosome.
Journal, issue, pagesElife, Vol. 14, Year 2025
Publish dateJan 29, 2025 (structure data deposition date)
AuthorsEapen, R. / Okoye, C. / Stubbs, C. / Schimpl, M. / Tischer, T. / Fisher, E.J. / Zacharopoulou, M. / Ferrer, F. / Barford, D. / Spring, D.R. ...Eapen, R. / Okoye, C. / Stubbs, C. / Schimpl, M. / Tischer, T. / Fisher, E.J. / Zacharopoulou, M. / Ferrer, F. / Barford, D. / Spring, D.R. / Lindon, C. / Phillips, C. / Itzhaki, L.S.
External linksElife / PubMed:40888475
MethodsX-ray diffraction
Resolution1.463 - 1.915 Å
Structure data

PDB-9i68:
Crystal structure of human Cdc20 bound to synthetic D-box peptide D21
Method: X-RAY DIFFRACTION / Resolution: 1.505 Å

PDB-9i69:
Crystal structure of human Cdc20 bound to synthetic D-box peptide D20
Method: X-RAY DIFFRACTION / Resolution: 1.463 Å

PDB-9i6a:
Crystal structure of human Cdc20 bound to synthetic D-box peptide D7
Method: X-RAY DIFFRACTION / Resolution: 1.915 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / APC/C / degron / D-box

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