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TitleSHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2503631122-e2503631122, Year 2025
Publish dateJan 2, 2025 (structure data deposition date)
AuthorsPerla, S. / Stiegler, A.L. / Yi, J.S. / Enyenihi, L. / Zhang, L. / Riaz, M. / An, E. / Qyang, Y. / Boggon, T.J. / Bennett, A.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:40854126
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-9mq5:
Crystal structure SHP2 tandem SH2 domains in complex with PZR doubly tyrosine phosphorylated ITIM peptide
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / SH2 domain / phosphotyrosine / ITIM / complex

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