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Structure paper

TitleA Dual-Specificity d-Peptide Antagonist of MDM2 and MDMX for Antitumor Immunotherapy.
Journal, issue, pagesJ. Med. Chem., Year 2025
Publish dateOct 26, 2020 (structure data deposition date)
AuthorsLiao, C. / Yan, J. / Tolbert, W.D. / Chen, X. / Pazgier, M. / Lu, W. / Zhan, C.
External linksJ. Med. Chem. / PubMed:40824889
MethodsX-ray diffraction
Resolution1.4 - 2.8 Å
Structure data

PDB-7kjm:
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-7kjn:
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsLIGASE/LIGASE INHIBITOR / MDM2 / P53 BINDING DOMAIN / D-PEPTIDE ACTIVATOR OF MDM2 / MDM2-D-PEPTIDE COMPLEX / HOST-VIRUS INTERACTION / LIGASE / METAL-BINDING / NUCLEUS / PHOSPHOPROTEIN / PROTO-ONCOGENE / UBL CONJUGATION PATHWAY / ZINC-FINGER / LIGASE-LIGASE INHIBITOR COMPLEX / MDMX / MDM2-LIKE P53 BINDING PROTEIN / P53-BINDING PROTEIN MDM4 / D-PEPTIDE ACTIVATOR OF MDMX / MDMX-D-PEPTIDE COMPLEX

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