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TitleThe structure of the mammalian bornavirus polymerase complex.
Journal, issue, pagesNat Commun, Vol. 16, Issue 1, Page 7508, Year 2025
Publish dateAug 13, 2025
AuthorsLoïc Carrique / Franziska Günl / Adrian Deng / Jonathan M Grimes / Jeremy R Keown /
PubMed AbstractBorna disease virus 1 (BoDV-1) is a non-segmented RNA virus with one of the smallest known RNA virus genomes. BoDV-1 replicates in the nucleus of infected cells using a virally encoded polymerase ...Borna disease virus 1 (BoDV-1) is a non-segmented RNA virus with one of the smallest known RNA virus genomes. BoDV-1 replicates in the nucleus of infected cells using a virally encoded polymerase complex composed of the large protein and phosphoprotein. Here, we present the BoDV-1 polymerase complex at resolutions up to 2.8 Å, describing the fully ordered large polymerase protein bound to tetrameric phosphoprotein. The complex is maintained through the ordered C-terminal region of one copy of the phosphoprotein. Analysis of the model reveals a conserved methyltransferase domain, though key S-adenosyl methionine binding residues are missing. While no RNA is observed in our models, analysis of a sample under reaction conditions induces an opening and closing of the template entry and exit channels, respectively. Higher-order polymerase assemblies suggest oligomerisation as a conserved feature of negative strand RNA virus polymerases. We provide a molecular framework to investigate bornavirus replication and transcription.
External linksNat Commun / PubMed:40804239 / PubMed Central
MethodsEM (single particle)
Resolution2.95 - 3.07 Å
Structure data

51765

9h1g

EMDB-51765, PDB-9h1g:
Structure of the borna disease virus 1 replication complex
Method: EM (single particle) / Resolution: 3.07 Å

51770

9h1q

EMDB-51770, PDB-9h1q:
Structure of the borna disease virus 1 replication core complex - reaction complex
Method: EM (single particle) / Resolution: 2.95 Å

51785

9h1y

EMDB-51785, PDB-9h1y:
Structure of the borna disease virus 1 replication full-length complex - reaction complex
Method: EM (single particle) / Resolution: 3.07 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • borna disease virus 1
KeywordsVIRAL PROTEIN / polymerase / phosphoprotein / bornavirus / RdRp

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