EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Profiling and Optimizing Targeted Covalent Inhibitors through EGFR-Guided Studies.
ジャーナル・号・ページ	J. Med. Chem., Vol. 68, Page 17917-17932, Year 2025
掲載日	2025年1月10日 (構造データの登録日)
著者	Damghani, T. / Chitnis, S.P. / Abidakun, O.A. / Patel, K.B. / Lin, K.S. / Ouellette, E.A. / Lantry, A.M. / Heppner, D.E.
リンク	J. Med. Chem. / PubMed:40801664
手法	X線回折
解像度	1.93 - 2.75 Å
構造データ	PDB-9msr: BDTX-1535 in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-9mss: Limertinib in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-9mst: Befotertinib in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-9nhw: Oritinib in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-9nis: Alflutinib in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-9nj7: Almonertinib in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å PDB-9njn: YK-029a in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-9nm0: AZ5104 (metabolite of AZD9291) in complex with WT EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.59 Å PDB-9os6: Canertinib (CI-1033) in complex with wild-type EGFR 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å
化合物	PDB-1brc: RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN ChemComp-HOH: WATER PDB-1byo: WILD-TYPE PLASTOCYANIN FROM SILENE PDB-1byn: SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I PDB-1byd: CRYSTAL STRUCTURES OF SOYBEAN BETA-AMYLASE REACTED WITH BETA-MALTOSE AND MALTAL: ACTIVE SITE COMPONENTS AND THEIR APPARENT ROLE IN CATALYSIS PDB 未公開エントリ PDB-1byk: Unknown entry PDB-1byl: BLEOMYCIN RESISTANCE PROTEIN FROM STREPTOALLOTEICHUS HINDUSTANUS PDB-1bys: CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE ChemComp-VO7: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide PDB-1cea: THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/INHIBITOR / Signaling / Cancer / Inhibitor / TRANSFERASE-INHIBITOR complex / TRANSFERASE / Kinase / Drug Discovery / Drug Development / Drug Resistance / Drug Resistance. / Cancer Drugs / Drug Toxicity / Covalent