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Structure paper

TitleCyclic tetraadenylate binding induces dimerization of protein dimers to activate a CRISPR-associated PIN nuclease.
Journal, issue, pagesNucleic Acids Res., Vol. 53, Year 2025
Publish dateOct 12, 2024 (structure data deposition date)
AuthorsWang, F. / Zhao, P. / Bi, X. / Zheng, R. / Tian, X. / Xu, J. / Jiang, S. / Li, G. / Shen, Y. / She, Q.
External linksNucleic Acids Res. / PubMed:40794864
MethodsX-ray diffraction
Resolution2.5 - 3 Å
Structure data

PDB-9jxw:
Crystal structure of SiRe_0806 from Sulfolobus islandicus
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9jxx:
Crystal structure of SiRe_0806 in complex with cA4
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • sulfolobus islandicus rey15a (archaea)
  • saccharolobus islandicus rey15a (archaea)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Sulfolobus islandicus / SiRe_0806 / cyclic oligo-adenylates (cOAs) / CARF domain / PIN domain / RNase / IMMUNE SYSTEM/RNA / IMMUNE SYSTEM-RNA complex

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