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TitleA pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers.
Journal, issue, pagesCancer Cell, Vol. 43, Page 1866-, Year 2025
Publish dateMar 20, 2025 (structure data deposition date)
AuthorsFeng, J. / Xiao, X. / Xia, X. / Min, J. / Tang, W. / Shi, X. / Xu, K. / Zhou, G. / Li, K. / Shen, P. ...Feng, J. / Xiao, X. / Xia, X. / Min, J. / Tang, W. / Shi, X. / Xu, K. / Zhou, G. / Li, K. / Shen, P. / Bao, R. / Wu, S. / Lin, M. / Yuan, K. / Lian, Z. / Hu, L. / Li, N. / Wu, Z. / Zhai, X. / Liu, X. / Hu, K. / Wu, J. / Ding, C. / Zhao, H. / Gong, X. / Zhang, S. / Jin, J. / Li, D. / Liu, M. / Ye, Y. / Ma, B. / Guo, R.T. / Zhang, A. / Pang, X.
External linksCancer Cell / PubMed:40780213
MethodsX-ray diffraction
Resolution1.8 - 2.35 Å
Structure data

PDB-9u50:
GDP-bound KRAS G12V in complex with MCB-294
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-9u5t:
GDP-bound KRAS G12D in complex with MCB-294
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-9usb:
GppNHp-bound KRAS G12D in complex with MCB-294
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-MG:
Unknown entry

PDB-1en3:
1A CRYSTAL STRUCTURES OF B-DNA REVEAL SEQUENCE-SPECIFIC BINDING AND GROOVE-SPECIFIC BENDING OF DNA BY MAGNESIUM AND CALCIUM

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / GDP-bound / inhibitor / GppNHp-bound

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