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Structure paper

TitleA cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis.
Journal, issue, pagesNat Commun, Vol. 16, Page 6781-6781, Year 2025
Publish dateSep 12, 2024 (structure data deposition date)
AuthorsUeno, A. / Takida, F. / Kita, T. / Ishii, T. / Himiyama, T. / Mabuchi, T. / Okamoto, Y.
External linksNat Commun / PubMed:40745177
MethodsX-ray diffraction
Resolution1.08 - 1.3 Å
Structure data

PDB-9jit:
Macrophage migration inhibitory factor S61H/Y100H mutant (MIF(S61H/Y100H))
Method: X-RAY DIFFRACTION / Resolution: 1.08 Å

PDB-9jiv:
Macrophage migration inhibitory factor Y100H mutant (MIF(Y100H))
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-9jiy:
Macrophage migration inhibitory factor S61H/Y100H mutant complexed with three Zinc ions (Zn3-MIF(S61H/Y100H)-L)
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-9jiz:
Macrophage migration inhibitory factor S61H/Y100H mutant complexed with three Zinc ions (Zn3-MIF(S61H/Y100H))
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-9jj0:
Macrophage migration inhibitory factor Y100H mutant complexed with three Zinc ions (Zn3-MIF(Y100H))
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-CO3:
CARBONATE ION

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsCYTOKINE / Macrophage migration inhibitory factor

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