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Structure paper

TitleMolecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases.
Journal, issue, pagesEmbo J., Vol. 44, Page 4867-4898, Year 2025
Publish dateMar 6, 2025 (structure data deposition date)
AuthorsMarquez-Monino, M.A. / Martinez Gascuena, A. / Azzam, T. / Persson, A. / Manzanares-Gomez, A. / Aguillo-Urarte, M. / Brown, T.T. / Montero-Sagarminaga, A. / Lood, R. / Naegeli, A. ...Marquez-Monino, M.A. / Martinez Gascuena, A. / Azzam, T. / Persson, A. / Manzanares-Gomez, A. / Aguillo-Urarte, M. / Brown, T.T. / Montero-Sagarminaga, A. / Lood, R. / Naegeli, A. / Connell, S.R. / Sastre, D.E. / Sundberg, E.J. / Trastoy, B.
External linksEmbo J. / PubMed:40745064
MethodsX-ray diffraction
Resolution1.94 - 2 Å
Structure data

PDB-9qdh:
Crystal structure of IgA protease (323-878) from Thomasclavelia ramosa
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9qdi:
Crystal structure of BF3526 peptidase from Bacteroides fragilis in complex with a peptide
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-POL:
N-PROPANOL

ChemComp-BU1:
1,4-BUTANEDIOL

ChemComp-HEZ:
HEXANE-1,6-DIOL

Source
  • thomasclavelia ramosa (bacteria)
  • bacteroides fragilis nctc 9343 (bacteria)
  • synthetic construct (others)
KeywordsHYDROLASE / IgA protease / peptidase / protease / IgA-P / M64 / metallopeptidase / metalloprotease / antibody / Ig / IgA / Thomasclavelia / metzincin / nephropathy / IgAN / hinge / BF3526 / Bacteroides / complex / substrate / product

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