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Structure paper

TitleStructural basis for the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2504208122-e2504208122, Year 2025
Publish dateAug 12, 2024 (structure data deposition date)
AuthorsPark, S.K. / Guo, M. / Stamos, J.L. / Kim, W. / Lee, S. / Zhang, Y.J. / Lambowitz, A.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:40729381
MethodsX-ray diffraction
Resolution2.61 - 2.77 Å
Structure data

PDB-9d4s:
Structure of G2L4 RT in complex with 15 nucleotide snapback substrate
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

PDB-9d5x:
Structure of G2L4 RT Apoenzyme
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-URE:
UREA

Source
  • gammaproteobacteria (g-proteobacteria)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / Reverse transcriptase / Microhomology-Mediated End-Joining / DNA repair. / Group II intron reverse transcriptase / Microhomology Mediated End Joining / DNA repair

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