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TitleMechanistic insights into the iron-sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2510269122-e2510269122, Year 2025
Publish dateDec 28, 2024 (structure data deposition date)
AuthorsLiu, H. / Shen, L. / Gong, X. / Zhou, X. / Huang, Y. / Zhou, Y. / Guo, Z. / Guo, H. / Wang, S. / Pan, L.
External linksProc. Natl. Acad. Sci. USA / PubMed:40705422
MethodsX-ray diffraction
Resolution1.73 - 1.92 Å
Structure data

PDB-9l8y:
Crystal structure of HERC2
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-9l93:
Crystal structure of NCOA4 in complex with HERC2
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

Source
  • homo sapiens (human)
KeywordsLIGASE / HERC2 / NCOA4 / Iron-Sulfur Cluster

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