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TitleCMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.
Journal, issue, pagesActa Pharm Sin B, Vol. 15, Page 3708-3724, Year 2025
Publish dateNov 10, 2023 (structure data deposition date)
AuthorsChen, Y. / Yuan, X. / Yan, W. / Zou, Y. / Wei, H. / Wei, Y. / Tang, M. / Ma, Z. / Yang, T. / Liu, K. ...Chen, Y. / Yuan, X. / Yan, W. / Zou, Y. / Wei, H. / Wei, Y. / Tang, M. / Ma, Z. / Yang, T. / Liu, K. / Xiong, B. / Hu, X. / Yang, J. / Chen, L.
External linksActa Pharm Sin B / PubMed:40698146
MethodsX-ray diffraction
Resolution2.26 Å
Structure data

PDB-8x2o:
RIPK2 in complex with K252
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals


ChemComp, No image

ChemComp-6IL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / inhibitor

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