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TitleDesign of intrinsically disordered region binding proteins.
Journal, issue, pagesScience, Vol. 389, Page eadr8063-eadr8063, Year 2025
Publish dateJun 21, 2024 (structure data deposition date)
AuthorsWu, K. / Jiang, H. / Hicks, D.R. / Liu, C. / Muratspahic, E. / Ramelot, T.A. / Liu, Y. / McNally, K. / Kenny, S. / Mihut, A. ...Wu, K. / Jiang, H. / Hicks, D.R. / Liu, C. / Muratspahic, E. / Ramelot, T.A. / Liu, Y. / McNally, K. / Kenny, S. / Mihut, A. / Gaur, A. / Coventry, B. / Chen, W. / Bera, A.K. / Kang, A. / Gerben, S. / Lamb, M.Y. / Murray, A. / Li, X. / Kennedy, M.A. / Yang, W. / Song, Z. / Schober, G. / Brierley, S.M. / O'Neill, J. / Gelb, M.H. / Montelione, G.T. / Derivery, E. / Baker, D.
External linksScience / PubMed:40674483
MethodsX-ray diffraction
Resolution3.15 - 4 Å
Structure data

PDB-9cce:
structure of DYNA_1b7
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-9ccf:
Crystal Structure of DA7-2
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsDE NOVO PROTEIN / de novo design / deep learning / disorder peptide / protein-peptide complex / disorder / intrinsically disordered protein

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