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TitleStructural modeling reveals viral proteins that manipulate host immune signaling.
Journal, issue, pagesBiorxiv, Year 2025
Publish dateJun 23, 2025 (structure data deposition date)
AuthorsTal, N. / Hadari, R. / Chang, R.B. / Osterman, I. / Jacobson, R. / Yirmiya, E. / Bechon, N. / Hochhauser, D. / Rivera, M.L. / Madhala, B. ...Tal, N. / Hadari, R. / Chang, R.B. / Osterman, I. / Jacobson, R. / Yirmiya, E. / Bechon, N. / Hochhauser, D. / Rivera, M.L. / Madhala, B. / Garb, J. / Wein, T. / Kranzusch, P. / Amitai, G. / Sorek, R.
External linksBiorxiv / PubMed:40672179
MethodsX-ray diffraction
Resolution1.62 Å
Structure data

PDB-9p8l:
Structure of Lockin in complex with 3'cADPR
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

Chemicals

ChemComp-OJC:
(2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione

ChemComp-HOH:
WATER

Source
  • phage metagenome (others)
KeywordsVIRAL PROTEIN / immune evasion / viral sponge

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